Steroid diffusion and binding in human stratum corneum
- 1 January 1984
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases
- Vol. 80 (12) , 3439-3444
- https://doi.org/10.1039/f19848003439
Abstract
The effects of hydration on diffusion in human stratum corneum have been inferred from the behaviour of a limited selection of steroids in whole human skin in vitro. Using nandrolone as a model steroid, an initial estimate of the activation energy for the diffusion process has been obtained, and, providing certain assumptions are valid, the free-energy change for the binding of nandrolone to sites within the stratum corneum has been estimated.This publication has 3 references indexed in Scilit:
- The diffusion of nandrolone through occluded and non-occluded human skinJournal of Pharmacy and Pharmacology, 1978
- The diffusion of nandrolone through hydrated human cadaver skinBritish Journal of Dermatology, 1976
- Existence of Reservoir in the Stratum CorneumArchives of Dermatology, 1963