Ligand-Modulated Palladium-Catalyzed Aerobic Alcohol Oxidations
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- 20 January 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Accounts of Chemical Research
- Vol. 39 (3) , 221-229
- https://doi.org/10.1021/ar040243m
Abstract
The discovery and investigation of ligand-modulated Pd-catalyzed aerobic alcohol oxidations is documented. The project has evolved from a simple empirical discovery that (−)-sparteine, in combination with PdII salts, facilitates the aerobic oxidative kinetic resolution of secondary alcohols to an in-depth physical organic investigation that has provided key insights into how new, more effective catalysts can be designed. Mechanistic investigations, the substrate scope for the catalysts developed, and implications to oxidation catalysis are discussed.Keywords
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