Understanding the Biologic Basis of Migraine

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Abstract
Until the 1988 classification of headaches by the International Headache Society, the various headache disorders were poorly defined, and migraine and tension-type headache were often viewed as part of a continuum.1 When the society's strict diagnostic criteria were applied to a general population, however, these were shown to be two distinct disorders.2 There are two main types of migraine.1 The first, migraine without aura (previously called common migraine), is characterized by headache attacks lasting 4 to 72 hours. The headache is usually severe, unilateral, pulsating, aggravated by physical activity, and accompanied by nausea, vomiting, photophobia (hypersensitivity to light), and phonophobia . . .