Anatomy and metabolism of the normal human brain studied by magnetic resonance at 1.5 Tesla.

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Abstract
Proton magnetic resonance (MR) images were obtained of the human head in magnetic fields as high as 1.5 Tesla (T) using slotted resonator high radio-frequency (RF) detection coils. The images showed no RF field penetration problems and exhibited an 11 (.+-. 1)-fold improvement in signal-to-noise ratio over a 0.12-T imaging system. The 1st localized P31, 13C and proton MR chemical shift spectra recorded with surface coils from the head and body in the same instrument showed relative concentrations of P metabolites, triglycerides and, when correlated with proton images, negligible lipid (-CH2-) signal from brain tissue on the time scale of the imaging experiment. Sugar PO4 and phosphodiester concentrations were significantly elevated in the head compared with muscle. This method should allow the combined assessment of anatomy, metabolism and biochemistry in both the normal and diseased brain.

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