Oxygen Changes in Tissues of Germfree and Conventional Mice after Inoculation of Bacterial Endotoxin

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Abstract
Bacterial endotoxin [Salmonella typhosa] injected i.p. into mice reduces the PO2 of tissues. The lowest value is reached in 24 hours. The PO2 levels in germfree mouse tissues are depressed more than those in conventional mice. Reduction in tissue PO2 evoked by endotoxin may be responsible for protection against wholebody exposure to ionizing radiation following endotoxin administration.

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