Electrophoretic Plasma Protein Patterns in Families with Hemophilia.

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Abstract
An electrophoretic anomaly, called a x-globulin, has been found in the plasma of all hemophiliacs studied (14). The same anomaly also has been observed in 8 members of hemophilic families who are not active bleeders (over 50% of this category), and who are not afflicted with any of the other diseases in which this anomaly has been found (acute idiopathic thrombocytopenia and Henoch-Schonlein purpura). The [alpha] x-globulin is seen in female as well as in male members of hemophilic families, unlike the bleeding manifestation of hemophilia, found only in males. There is a definite relationship between the prothrombin utilization and the appearance of the [alpha] x-globulin anomaly in the plasma of members of hemophilic families.

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