HLA-DR2 and Narcolepsy
Open Access
- 1 March 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Sleep
- Vol. 9 (1) , 149-152
- https://doi.org/10.1093/sleep/9.1.149
Abstract
A positive association between HLA-DR2, DQw1, and narcolepsy was documented in 23 French caucasoid narcoleptic patients, 18 who were heterozygous for DR2 and 5 who were possibly homozygous. An autoimmune mechanism of narcolepsy is proposed with three successive stages, as well as relevant methodology for further investigation. A dominant mode of inheritance of narcolepsy, with an incomplete penetrance, is suggested although not yet evidenced.Keywords
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