Congenital Malformations Induced by Ethyl-urethan in Mouse Embryos

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Abstract
Pregnant mice from our colony originating from a mixed strain of our country were injected with a 10 % ethyl-urethan aqueous solution in a dosage of 1.5 mg per g of body weight, and its effects on the development of the fetuses were studied, the results of which may be summarized as follows:1. Ethyl-urethan a d ministration before the 9th day of gestation revealed that it apparently suspended the implantation of the ovum, or rendered a lethal effect upon them and it induces no anomalies in the survivors.2. When ethyl-urethan was administered during the 9-12th day of gestation, it had a potent teratogenic, lethal, and growth suppressing effect upon the fetuses.3. As for th e types of malformations, most ones were found in the skeletal system, especially as the various digital malformations (maldirection, syndactyly, adactyly) and cleft palates, which appeared in many cases. Besides, malformations of the neck region, reduction of tail length, or an encephalocele were found.4. No abnormalities in the placentae of the malformed fetuses were recognized macroscopically or histologically.5. It is probable that the above mentioned teratogenic effect of ethyl-urethan originated in the disturbed organogenesis.

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