The role of exercise and PGC1α in inflammation and chronic disease
Top Cited Papers
- 1 July 2008
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 454 (7203) , 463-469
- https://doi.org/10.1038/nature07206
Abstract
Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1α has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.Keywords
This publication has 79 references indexed in Scilit:
- Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1α and oxidative phosphorylationProceedings of the National Academy of Sciences, 2008
- Large-scale chemical dissection of mitochondrial functionNature Biotechnology, 2008
- AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1αProceedings of the National Academy of Sciences, 2007
- A cytokine-mediated link between innate immunity, inflammation, and cancerJournal of Clinical Investigation, 2007
- PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophyGenes & Development, 2007
- Inflammation as a causative factor in the aetiology of Parkinson's diseaseBritish Journal of Pharmacology, 2007
- Inflammation and metabolic disordersNature, 2006
- PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcriptionProceedings of the National Academy of Sciences, 2006
- PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetesNature Genetics, 2003
- Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibresNature, 2002