The PYRIN Connection
Open Access
- 6 September 2004
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 200 (5) , 551-558
- https://doi.org/10.1084/jem.20032234
Abstract
Periodic fever syndromes (PFSs) comprise a subset of the hereditary autoinflammatory disorders that are defined by recurrent self-resolving attacks of systemic inflammatory reactions in the absence of infection or autoimmunity. Recent advances have led to the discovery that members of a new family of genes, the PYRIN family, account for several hereditary PFSs. Here we discuss new insights into the function of PYRIN proteins and the molecular basis of PFSs.Keywords
This publication has 45 references indexed in Scilit:
- Heterotypic interactions among NACHT domains: implications for regulation of innate immune responsesBiochemical Journal, 2004
- Subcellular localisation of marenostrin/pyrin isoforms carrying the most common mutations involved in familial Mediterranean fever in the presence or absence of its binding partner ASCJournal of Medical Genetics, 2004
- ASC is a Bax adaptor and regulates the p53–Bax mitochondrial apoptosis pathwayNature Cell Biology, 2004
- A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathwayOncogene, 2003
- The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappaB and pro-caspase-1 regulationBiochemical Journal, 2003
- Targeted Disruption of Pyrin, the FMF Protein, Causes Heightened Sensitivity to Endotoxin and a Defect in Macrophage ApoptosisPublished by Elsevier ,2003
- Interaction between Pyrin and the Apoptotic Speck Protein (ASC) Modulates ASC-induced ApoptosisJournal of Biological Chemistry, 2001
- An Induced Proximity Model for NF-κB Activation in the Nod1/RICK and RIP Signaling PathwaysJournal of Biological Chemistry, 2000
- A candidate gene for familial Mediterranean feverNature Genetics, 1997
- Ancient Missense Mutations in a New Member of the RoRet Gene Family Are Likely to Cause Familial Mediterranean FeverCell, 1997