MODIFICATION OF THE EFFECTIVENESS OF GONADOTROPHIC EXTRACTS

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Abstract
During the last few years gonadotrophic extracts from various sources have been tested in many ways, in attempts to determine the number of active principles involved and the maximum activity of given preparations. It has been found that the effect of two extracts, when given together, may be much greater than the sum of the effects when they are administered singly. This is ascribed by many writers to an improved balance in the combined extract, of two different gonadotrophic principles, one follicle-stimulating and the other luteinizing. Other writers, however, especially Saunders and Cole [1938], regard the question of different hypophyseal principles as still unsettled, and attribute the greater effectiveness of combined extracts to delayed absorption of the active principle, since it is known that the addition of metallic salts and other inert substances may greatly increase the effectiveness of hypophyseal gonadotrophic preparations. In the present paper it is proposed to

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