Is predisposition to pemphigus vulgaris in Jewish patients mediated by HLA‐Dw10 and DR4?

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Abstract
Israeli Jewish pemphigus vulgaris (PV) patients (21) were studied for the HLA-D lymphocyte defined determinants and the serologically defined antigens of the HLA-A, B and DR series. HLA-D typing revealed that Dw10 is significantly associated with PV: 86% of patients vs. 18% of controls carried Dw10, and DR4 was present in 86% of patients as compared to 38% in the controls. The most striking observation was that all Dw10 positive patients were also positive for DR4, and no other patient carried DR4 alone. The relative risk for a Dw10-DR4 carrier to develop PV was estimated at 31.9, higher than that observed for Dw10 alone (RR 26.7) or DR4 alone (RR 9.6). Thus, HLA-Dw10 may predispose for pemphigus vulgaris.