Evidence for mediation of a neuronal interaction by a behaviorally active peptide.

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Abstract
Egg laying hormone, a peptide neurohormone with an approximate MW of 6000, was isolated from the region of the abdominal ganglion of Aplysia californica that contains the neuroendocrine bag cells and purified by gel filtration chromatography, isoelectric focusing and dialysis. A 1-min local application of egg laying hormone to the identified neuron R15 produced prolonged (> 1 h) augmentation of impulse activity in this neuron. The distinctive quality and prolonged duration of the response are apparently identical to the previously described response to electrically elicited bag cell activity. Egg laying hormone is the mediator of this prolonged neuronal interaction.