Beyond the role of glutamate as a neurotransmitter
Top Cited Papers
- 1 September 2002
- journal article
- review article
- Published by Springer Nature in Nature Reviews Neuroscience
- Vol. 3 (9) , 748-755
- https://doi.org/10.1038/nrn916
Abstract
Glutamate is the principal excitatory neurotransmitter of the central nervous system, but many studies have expanded its functional repertoire by showing that glutamate receptors are present in a variety of non-excitable cells. How does glutamate receptor activation modulate their activity? Do non-excitable cells release glutamate, and, if so, how? These questions remain enigmatic. Here, we review the current knowledge on glutamatergic signalling in non-neuronal cells, with a special emphasis on astrocytes.Keywords
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