Toxic and Possible Carcinogenic Effects of 4-AlIyl-1,2-Methylenedioxybenzene (Safrole) in Rats on Deficient Diets
- 1 January 1961
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 4 (1) , 1-11
- https://doi.org/10.1159/000134986
Abstract
4-allyl-1,2-methylenedioxybenzene (Safrole) was fed to CFN male rats on a riboflavin, tocopherol and casein-deficient diet for up to one year at the 0.1% and 1% level. Safrole at the 1% level was toxic and produced weight loss, hepatic adenomas, testicular atrophy and bone marrow depletion. At the 0.1% level it had no effect. Riboflavin supplement did not alter the Safrole effect. Tocopherol supplement decreased the nutritional cirrhosis but had no effect on adenomatosis. Casein supplement enhanced Safrole-induced adenomatosis.Keywords
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