USEFULNESS OF THIORIDAZINE FOR TREATING CHILDHOOD DISORDERS - FACT OR FOLKLORE

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 84  (4) , 331-338
Abstract
Studies of thioridazine (Mellaril) use for treating childhood behavior disorders were reviewed with a special emphasis on methodology. The caliber of these studies was unsatisfactory and measures of drug effect have tended to stress global rather than specific changes, resulting in little qualitative information being available. Examination of subgroups of children treated with thioridazine failed to reveal different levels of drug responsiveness. Few investigators have attempted to assess cognitive effects, but the evidence suggests that cognitive dulling may be an unwanted effect of treatment. Further research of sufficient quality is needed.