The Effects of Salt and Meclofenamate Administration on the Hypertension of Spontaneously Hypertensive Rats

Publisher Website
Google Scholar
Abstract
The effects of prolonged (3 mos) high sodium intake and meclofenamate were studied in 2 groups of male SHR. Group 1 (6 rats) received 1% NaCl in tap water and Group 2 (8 rats) received 1% NaCl in tap water plus 50 μg of meclofenamate per ml of drinking fluid. Renal metabolic and hemodynamic studies in the unanesthetized unrestrained state, showed that the meclofenamate treated rats had higher arterial pressures (p<.005), left ventricular weight (p<.05) and renal vascular resistance (p<.005); lower glomerular filtration rate (p<.005) than the control rats. The hematocrit and right ventricular weight were similar in the two groups of rats. This study has demonstrated that the combination of high sodium intake and meclofenamate have a greater damaging effect on the arterial pressure and renal function of SHR than salt alone.