Calcium/Calmodulin-dependent Kinase II Regulation of Cardiac Ion Channels
- 1 September 2009
- journal article
- review article
- Published by Wolters Kluwer Health in Journal of Cardiovascular Pharmacology
- Vol. 54 (3) , 180-187
- https://doi.org/10.1097/fjc.0b013e3181a25078
Abstract
Calcium/calmodulin-dependent kinase II (CaMKII) is a multifunctional serine/threonine kinase expressed abundantly in the heart. CaMKII targets numerous proteins involved in excitation-contraction coupling and excitability, and its activation may simultaneously contribute to heart failure and cardiac arrhythmias. In this review, we summarize the modulatory effects of CaMKII on cardiac ion channel function and expression and illustrate potential implications in the onset of arrhythmias via a computer model.Keywords
This publication has 78 references indexed in Scilit:
- Ca/Calmodulin Kinase II Differentially Modulates Potassium CurrentsCirculation: Arrhythmia and Electrophysiology, 2009
- Calmodulin Mediates Differential Sensitivity of CaMKII and Calcineurin to Local Ca2+ in Cardiac MyocytesBiophysical Journal, 2008
- Role of activated CaMKII in abnormal calcium homeostasis and INa remodeling after myocardial infarction: Insights from mathematical modelingJournal of Molecular and Cellular Cardiology, 2008
- Ca2+/Calmodulin-dependent Protein Kinase II-dependent Remodeling of Ca2+ Current in Pressure Overload Heart FailureJournal of Biological Chemistry, 2008
- Modulation of late sodium current by Ca2+, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differencesAmerican Journal of Physiology-Heart and Circulatory Physiology, 2008
- Simulation of Ca-Calmodulin-Dependent Protein Kinase II on Rabbit Ventricular Myocyte Ion Currents and Action PotentialsBiophysical Journal, 2007
- Regulation of Ca2+and electrical alternans in cardiac myocytes: role of CAMKII and repolarizing currentsAmerican Journal of Physiology-Heart and Circulatory Physiology, 2007
- Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channelsJournal of Clinical Investigation, 2006
- Calmodulin kinase II accelerates L‐type Ca2+ current recovery from inactivation and compensates for the direct inhibitory effect of [Ca2+]i in rat ventricular myocytesThe Journal of Physiology, 2006
- Calcium/calmodulin-dependent protein kinase IIdelta associates with the ryanodine receptor complex and regulates channel function in rabbit heartBiochemical Journal, 2004