Non-chromaffin Paragangliomatosis Manifesting as a Cold Thyroid Nodule

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Abstract
A “cold” thyroid nodule in a 36-year-old woman manifested high activity with a 75Se-methionine scan. The light and electron microscopic features of the excised tumor were diagnostic of a non-chromaffin paraganglioma, or less likely, a medullary carcinoma of the thyroid without amyloid formation. Subsequently, another non-chromaffin paraganglioma was removed from the bifurcation of each common carotid artery. All three tumors had identical histologic, histochemical and electron microscopic features. They are considered to represent three independent primary non-chromaffin paragangliomas. The relationship of these tumors to the series of polypeptide hormone-producing cells originating from the neural crest (“APUD series”) is discussed.

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