DIFFERENT LOCAL THERAPEUTIC EFFECTS OF VARIOUS POLYSACCHARIDES ON MH134 HEPATOMA IN MICE AND ITS RELATION TO INFLAMMATION INDUCED BY THE POLYSACCHARIDES
- 1 January 1984
- journal article
- research article
- Vol. 75 (5) , 459-465
Abstract
The local antitumor activities and inflammation-inducing activities of various antitumor polysaccharides were examined, and the relation between the 2 types of activity was studied. The tested antitumor polysaccharides included MG (a mannoglucan prepared from the culture fluid of Microellobosporia grisea), lentinan, bacterial [Escherichia coli] lipopolysaccharide, TAK (a glucan from Alcaligenes faecalis) and their derivatives. Local antitumor activity was tested by intratumoral administration of the polysaccharides 4,7 and 10 days after inoculation of MH134 [mouse] hepatoma intradermally into the abdomen of C3H/He mice. MG and its derivatives showed strong local antitumor activity. Inflammation-inducing activity was assayed by measuring footpad swelling and accumulation of i.v.-injected 51Cr-labeled spleen cells after injection of the test materials into the footpads of C3H/He mice. TAK had the strongest inflammation-inducing activity among the polysaccharides tested. No close correlation was found between the local antitumor activity and the inflammation-inducing activity.This publication has 8 references indexed in Scilit:
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