SMALL INTESTINAL CARCINOMA IN SHEEP

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Abstract
A high prevalence of small intestinal carcinoma was found, 17 cases in a survey of 6248 sheep (0.272%), from southern New South Wales. The neoplasm appeared on the serosal surface of the jejeunum and ileum as a ring of dense white fibrous tissue which caused stenosis and cranial dilation of the intestine. The mucosa and muscularis were thickened and folded but otherwise grossly normal except for 3 cases where small polyps were present. Metastatic lesions occurred regularly in mesenteric lymph nodes and sclerotic deposits were often present on the surface of abdominal viscera. In 1 case metastatic nodules were found throughout the liver and lungs. Histologically, the glandular architecture of the mucosa and submucosa was disturbed and thickened with fibrous tissue. The muscularis was intact; an intense desmoplastic reaction under the serosa contained scattered islands of PAS[periodic acid-Schiff]-positive epithelial cells; distinct acini were uncommon and mitotic figures rare.