An Orally Bioavailable Pyrrolinone Inhibitor of HIV-1 Protease: Computational Analysis and X-ray Crystal Structure of the Enzyme Complex
- 1 August 1997
- journal article
- letter
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 40 (16) , 2440-2444
- https://doi.org/10.1021/jm970195u
Abstract
No abstract availableThis publication has 16 references indexed in Scilit:
- The design and synthesis of 2,5-linked pyrrolinones. A potential non-peptide peptidomimetic scaffoldBioorganic & Medicinal Chemistry, 1996
- Design and synthesis of nonpeptide peptidomimetic inhibitors of reninBiopolymers, 1995
- Design and synthesis of peptidomimetic inhibitors of HIV-1 protease and renin. Evidence for improved transportJournal of Medicinal Chemistry, 1994
- Electrophilic activation of the Horner-Wadsworth-Emmons-Wittig reaction: highly selective synthesis of dissymmetric olefinsJournal of the American Chemical Society, 1992
- An unbounded systematic search of conformational spaceJournal of Computational Chemistry, 1991
- Design and conformational analysis of several highly potent bradykinin receptor antagonistsJournal of Medicinal Chemistry, 1991
- Semianalytical treatment of solvation for molecular mechanics and dynamicsJournal of the American Chemical Society, 1990
- Empirical and ab initio estimates of the stabilities of fluorine-containing cationsJournal of the American Chemical Society, 1990
- Structure of Complex of Synthetic HIV-1 Protease with a Substrate-Based Inhibitor at 2.3 Å ResolutionScience, 1989
- Affinity purification of the HIV-1 proteaseBiochemical and Biophysical Research Communications, 1989