Isoxazoles with antipicornavirus activity
- 1 June 1985
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 28 (6) , 748-752
- https://doi.org/10.1021/jm00383a010
Abstract
The synthesis and evaluation of a series of 3,5-disubstituted isoxazoles as antipicornavirus agents led to the discovery of several compounds effective in vitro against rhinovirus type 2 and poliovirus type 2. Compound 32 [5-[7-(2-chloro-4-methoxyphenoxy)heptyl]-3-methylisoxazole] was more effective than 4'',6-dichloroflavan against both viruses and was evaluated orally in mice infected intracerebrally with polio-2. A 31 mg/kg bid [twice a day], compound 32 showed a 53% survival rate as compared to 22% for the nonmedicated animals.This publication has 3 references indexed in Scilit:
- Prevention of human poliovirus-induced paralysis and death in mice by the novel antiviral agent arildoneAntimicrobial Agents and Chemotherapy, 1982
- 4′,6-Dichloroflavan (BW683C), a new anti-rhinovirus compoundNature, 1981
- Antiviral activity of some .beta.-diketones. 2. Aryloxy alkyl diketones. In vitro activity against both RNA and DNA virusesJournal of Medicinal Chemistry, 1977