Oscillation of Cyclic Adenosine Monophosphate Concentration during the Myocardial Contraction Cycle
- 30 November 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 182 (4115) , 933-934
- https://doi.org/10.1126/science.182.4115.933
Abstract
The concentration of adenosine 3',5'-monophosphate (cyclic AMP) rises and falls during each myocardial contraction cycle. Peak concentrations of cyclic AMP precede peak development of systolic tension. Epinephrine alters the normal oscillation in myocardial cyclic AMP and increases both diastolic and systolic concentrations of the cyclic nucleotide. These transient changes in myocardial cyclic AMP indicate a potential role for cyclic AMP as a beat-to-beat regulator of myocardial contractility.Keywords
This publication has 12 references indexed in Scilit:
- Newer Developments in the Determination of Cyclic AMP and Other Cyclic Nucleotides, Adenylate Cyclase, and PhosphodiesterasePublished by Wiley ,1974
- Cyclic adenosine 3′,5′-monophosphate-dependent protein kinase stimulation of calcium uptake by canine cardiac microsomesJournal of Molecular and Cellular Cardiology, 1972
- Phosphorylation of the Inhibitor Component of Troponin by Phosphorylase KinaseJournal of Biological Chemistry, 1972
- A simple and sensitive saturation assay method for the measurement of adenosine 3′:5′-cyclic monophosphateBiochemical Journal, 1971
- A Protein Binding Assay for Adenosine 3′:5′-Cyclic MonophosphateProceedings of the National Academy of Sciences, 1970
- Cyclic AMP and calcium uptake of the sarcoplasmic reticulum in relation to increased rate of relaxation under the influence of catecholaminesCardiovascular Research, 1970
- Mechanism of Action of Epinephrine and Glucagon on the Canine Heart: EVIDENCE FOR INCREASE IN SARCOTUBULAR CALCIUM STORES MEDIATED BY CYCLIC 3',5'-AMPCirculation Research, 1969
- An Adenosine 3′,5′-Monophosphate-dependent Protein Kinase from Escherichia coliJournal of Biological Chemistry, 1969
- Effect of Epinephrine on Phosphorylase b Kinase in Perfused Rat HeartsJournal of Biological Chemistry, 1966
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951