Treatment of Cystinuria with Thiola (α-Mercaptopropionyl Glycine)
- 1 January 1975
- journal article
- research article
- Published by Elsevier in European Urology
- Vol. 1 (5) , 227-228
- https://doi.org/10.1159/000455629
Abstract
Nine cystinuric patients (8 females and 1 male) with recurrent L-cystine stone formation have been treated since 1971 with the new drug Thiola (α-mercaptopropionyl glycine). Thiola was found to be more effective than D-penicillamine in dissolving L-cystine. In two cases no recurrence took place after 27 and 42 months, respectively. In one case a partial dissolution was observed after 20 months of Thiola administration. In four cases further stone growth was stopped. In the last two cases stone growth occurred even after administration of Thiola. Tolerance of the drug was good, and no serious effects were observed sufficient to interrupt treatment.Keywords
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