The sennoside constituents of Rhei Rhizoma and Sennae Folium as inhibitors of serum monoamine oxidase.

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Abstract
Four (in total) compounds with inhibitory effects on the activity of bovine serum monoamine oxidase were isolated from the methanol-water extracts of Rhei Rhizoma (Daiou) and Sennae Folium (Senna), and identified as sennosides A, B, E and F. Among them, sennosides A and B were obtained from both Rhei Rhizoma and Sennae Folium, while sennosides E and F were detected only in the former. The 50% inhibitory concentrations of the four sennosides were 17, 9, 24 and 13 .mu.M, respectively, and the type of inhibition by sennosides A and B with respect to allylamine as the substrate was non-competitive.