Simplex Optimization of Reaction Yields
- 5 September 1975
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 189 (4205) , 805-806
- https://doi.org/10.1126/science.189.4205.805
Abstract
The sequential simplex algorithm, an efficient optimization strategy, rapidly improved reaction yield as a function of time and temperature in the synthesis of π-C5H5Mo(CO)2CSN(CH3)2. The work demonstrates the feasibility and efficiency of the simplex design and suggests its application and usefulness in other syntheses.Keywords
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