Crystal Structure of a 1,4-Dihydropyridine with Enantiomers Showing Opposite Effects on Calcium Channels: Structural Features of Calcium Channel Agonists and Antagonists.

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Abstract
The structure of the calcium channel modulator isopropyl 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-5-nitro-3-pyridinecarboxylate has been determined by X-ray analysis. Structural and stereochemical features are discussed in relation to previously determined structures of calcium agonists and antagonists of the 1,4-dihydropyridine type, and in relation to a newly proposed model for the dihydropyridine binding site.