THE ANTAGONISM BETWEEN INSULIN AND PITUITARY EXTRACT
- 1 June 1928
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1908)
- Vol. 41 (6) , 875-882
- https://doi.org/10.1001/archinte.1928.00130180108007
Abstract
The pituitary body has for a long time been known to play a part in the mechanism that controls carbohydrate metabolism. Goetsch, Cushing and Jacobson1noted the high carbohydrate tolerance that accompanies pituitary deficiency, and they confirmed Borchardt's2previous assertion that the injection of pituitary extract caused hyperglycemia. Stenström3made the apparently conflicting observation that pituitary extract inhibited the hyperglycemia and glycosuria caused by injections of epinephrine hydrochloride. This was afterward confirmed by Burn4who was led thereby to speculate that pituitary extract should enhance the action of insulin. He found the opposite to be true,5namely, that posterior lobe extract, when injected into rabbits simultaneously with insulin, "had a powerful antagonistic effect on the action of insulin" as well as on that of epinephrine hydrochloride. Olmstead and Logan,6in their work with decerebrated cats, reached the same conclusion, and the studies of Joachimoglu and Metz,7Laura,8and others addedThis publication has 0 references indexed in Scilit: