Effects of 16α-OH-Δ4- and Δ5-Pregnene Compounds with Respect to Electrolyte Excretion of Aldosterone
- 1 March 1963
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 72 (3) , 397-402
- https://doi.org/10.1210/endo-72-3-397
Abstract
The effect of 16α-hydroxylated Δ4- and Δ5 pregnene compounds on electrolyte excretion was studied in adrenalectomized rats. Hydrocortisone diminished the sodium-retaining action of aldosterone and enhanced the potassium-excreting effect of aldosterone. When this steroid was hydroxylated at C-16 these effects were decreased. Progesterone diminished the sodium-retaining effect of aldosterone without significantly affecting the potassium excretion. 16α-Hydroxyprogesterone and 17α-hydroxyprogesterone were less effective in inhibiting the sodium-retaining effect of aldosterone than progesterone. Δ5-Pregnene compounds such as dehydroisoandrosterone, 16α-hydroxydehydroisoandrosterone, pregnenolone, 16α-hydroxypregnenolone and 17α-hydroxypregnenolone did not exert a significant effect on the excretion of water and electrolytes, nor did they modify the electrolyte effect of aldosterone.Keywords
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