Acute conduction velocity changes in guinea-pigs after administration of diphenylhydantoin
Open Access
- 1 October 1976
- journal article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 39 (10) , 995-1000
- https://doi.org/10.1136/jnnp.39.10.995
Abstract
Motor nerve conduction velocity was measured after dosing guinea-pigs with 200-400 μmol/kg diphenylhydantoin (DPH) daily for three to four days. Conduction velocity fell by a mean value of 13% in animals that achieved plasma DPH levels over 200 μmol/l. There was no change in velocity with DPH levels below this value.Keywords
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