The activation of protein kinase C is not necessary for the monoclonalantibody‐induced modulation of CD3 and CD4 antigens

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Abstract
We studied the effect of staurosporine, a potent inhibitor of protein kinase C (PKC) activity, on the phorbol ester‐ or monoclonal antibody (mAb)‐induced modulation of CD3 and CD4 surface antigens. Staurosporine (10−5 M) completely inhibited phorbol ester‐induced modulation but had no effect on that induced by mAb. These results indicate that the down‐regulation of CD3 and CD4 observed after activation of the cells by the corresponding mAb is independent from PKC‐mediated phosphorylations, and thus that the activation of PKC is sufficient but not necessary to induce the modulation of CD3 and CD4 antigens.

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