Mammaglobin A: A Promising Marker for Breast Cancer
Open Access
- 1 August 2002
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 48 (8) , 1362-1364
- https://doi.org/10.1093/clinchem/48.8.1362
Abstract
Most tumor markers in routine clinical practice lack organ specificity ( 1). For example, CA 15-3, BR 27.29, and carcinoembryonic antigen, which are widely used serum markers for breast cancer, can be increased in patients with most types of adenocarcinoma, especially if distant metastases are present [for a review, see Ref. ( 2)]. Using a modified differential display technique, Watson and Fleming ( 3)( 4) identified a novel gene that appeared to be expressed only in breast tissue. This gene, which was designated mammaglobin (MG), was found to encode a 93-amino acid protein with a predicted molecular mass of 10.5 kDa ( 4).Keywords
This publication has 7 references indexed in Scilit:
- Mammaglobin Is Found in Breast Tissue as a Complex with BU101Biochemistry, 2001
- Clinical Uses of Tumor Markers: A Critical ReviewCritical Reviews in Clinical Laboratory Sciences, 2001
- Transcriptional Complementarity in Breast Cancer: Application to Detection of Circulating Tumor CellsMolecular Diagnosis, 2001
- All Human Genes of the Uteroglobin Family Are Localized on Chromosome 11q12.2 and Form a Dense ClusterAnnals of the New York Academy of Sciences, 2000
- Mammaglobin B as a novel marker for detection of breast cancer micrometastases in axillary lymph nodes by reverse transcription‐polymerase chain reactionBreast Cancer Research and Treatment, 1999
- CA 15-3 and Related Mucins as Circulating Markers in Breast CancerAnnals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1999
- Identification of Mammaglobin B, a Novel Member of the Uteroglobin Gene FamilyGenomics, 1998