Reaction Products of Styrene Oxide with Deoxynucleosides and DNA In Vitro
- 1 January 1986
- book chapter
- Published by Springer Nature
- Vol. 9, 281-285
- https://doi.org/10.1007/978-3-642-71248-7_45
Abstract
The reaction of styrene oxide with deoxynucleosides and DNA were carried out in aqueous conditions at pH 7.4 and in acetic acid, to prepare large quantities of reaction products. The purification of the products were performed by HPLC and characterized by UV spectra in neutral, acid and alkali pH. The main products identified were 7-, N2-, O6-alkyldeoxyguanosine, 1-, N6-alkyldeoxyadenosine, N4-, 3-, and O2-alkyldeoxycytidine. In acetic acid additionally 3-alkyladenine and O4-alkylthymidine were formed. In DNA incubations the dominant product isolated was 7-alkylguanine. N2-guanine was also detected.Keywords
This publication has 3 references indexed in Scilit:
- Reaction products of styrene oxide with guanosine in aqueous mediaCarcinogenesis: Integrative Cancer Research, 1984
- Mutagenicities of styrene oxide derivatives on bacterial test systems: Relationship between mutagenic potencies and chemical reactivityChemico-Biological Interactions, 1981
- Mutagenicity of styrene and styrene oxideMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1977