Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel
- 30 October 1987
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 238 (4827) , 692-694
- https://doi.org/10.1126/science.3118464
Abstract
The Drosophila gene, dorsal , is a maternal effect locus that is essential for the establishment of dorsal-ventral polarity in the developing embryo. The dorsal protein was predicted from the complementary DNA sequence; it is almost 50 percent identical, over an extensive region, to the protein encoded by the avian oncogene v- rel , its cellular homolog, c- rel , and a human c- rel fragment. The oncogene v- rel is highly oncogenic in avian lymphoid, spleen, and bone marrow cells.Keywords
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