IMMUNE-RESPONSE IN SWINE GIVEN SOLUBLE-ANTIGENS FROM GROUP-E STREPTOCOCCUS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 40  (11) , 1553-1557
Abstract
Swine were given a series of injections of soluble or whole cell antigens [Ag] of group E Streptococcus (GES). Swine given autoclaved extracts developed greater amounts of antibody to anti-phagocytic factor (as detected with bactericidal and long-chain tests) than did swine given pepsin-extracted or whole cell Ag. The swine given extract developed fewer abscesses when challenge exposed with live virulent GES added to their feed. Swine given injections of concentrated autoclaved extract developed higher anti-phagocytic factor antibody titers than did control swine given injections of physiologic saline solution. When challenge exposed with live virulent GES by exposure to carrier swine, swine that were given extract developed 71.4% fewer abscesses than did the control swine. Of the abscesses in the swine that were given extract, 58.3% were less than 1 cm in diameter as compared with 38.2% of the abscesses in the controls. Development of some abscesses was apparently arrested in vaccinated swine. A degree of immunity to streptococcal lymphadenitis of swine can apparently be induced by vaccinating swine with non-living GES Ag.

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