Ascertainment in the sequential sampling of pedigrees
- 1 October 1977
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 12 (4) , 208-212
- https://doi.org/10.1111/j.1399-0004.1977.tb00928.x
Abstract
Provided all observed families are included in the pedigree analysis, even those which appeared uninteresting or sporadic and were not sampled further, and provided a decision to continue sampling is made conditional on types observed up to that point, the correct likelihood for the mode of inheritance may be easily computed. This opens the way for a more detailed study of the wider problem of optimal sampling rules on pedigrees.Keywords
This publication has 4 references indexed in Scilit:
- Probability functions on complex pedigreesAdvances in Applied Probability, 1978
- Calculation of risk factors and likelihoods for familial diseasesComputers and Biomedical Research, 1976
- Hyperlipidemia in Coronary Heart Disease II. GENETIC ANALYSIS OF LIPID LEVELS IN 176 FAMILIES AND DELINEATION OF A NEW INHERITED DISORDER, COMBINED HYPERLIPIDEMIAJournal of Clinical Investigation, 1973
- A General Model for the Genetic Analysis of Pedigree DataHuman Heredity, 1971