Effects of gonadectomy and hypophysectomy on the pineal body in the mouse: A quantitative morphological study

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Abstract
A quantitative morphological study was made to assess the effects of gonadectomy and hypophysectomy on the pineal in the mouse. Gonadectomy caused a slight increase in the pineal volume whereas hypophysectomy induced a marked decrease. The increase in pineal volume after gonadectomy was associated primarily with slight enlargement of pineal cells in the peripheral area of the gland, and the larger decrease in pineal volume after hypophysectomy correlated with marked atrophy of pineal cells throughout the entire gland.