ALTERED SURFACE MORPHOLOGY OF CONCANAVALIN A TRANSFORMED THYMIC LYMPHOCYTES AS SEEN BY SCANNING ELECTRON-MICROSCOPY

  • 1 January 1976
    • journal article
    • research article
    • Vol. 24  (6) , 389-395
Abstract
The surface architecture of normal and concanavalin A transformed thymic lymphocytes was studied under the scanning electron microscope (SEM), employing different modes of cell preparation and fixation. Murine thymic lymphocytes have a relatively uniform surface architecture and display few microvilli, irrespective of the mode of fixation used in their preparation for SEM. When cells are incubated for 72 h no gross changes in surface morphology are noted. After incubation with concanavalin A for 72 h, the transformed cells display multiple microvilli and are earily distinguished from their relatively smooth normal non-transformed counterparts. The results are reviewed in the light of current knowledge on the surface architecture of lymphocytes and the factors influencing lymphocyte surface topography are discussed.

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