Three new heliangolides from Tithonia rotundifolia

Abstract
Further studies on metabolites of Tithonia rotundifolia(Mill.) Blake have furnished three new germacranolides, tithonin (1a), O-methyltithonin (1b), and 14-deacetyl-17,18-dihydrorotundin (2). Tithonin is a novel hemiacetal heliangolide oxygenated at C-14.

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