Asymmetric synthesis of (+)-citrinin using an ortho-toluate carbanion generated by a chiral base
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 7,p. 520-521
- https://doi.org/10.1039/c39870000520
Abstract
The carbanion (3), generated using the chiral lithium amide base (1), undergoes enantioselective addition to acetaldehyde and acetone with a high degree of asymmetric induction at the nucleophilic centre; the reaction with acetaldehyde is exploited in an enantioselective synthesis of (+)-citrin (10).Keywords
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