E.E.G. MONITORING FOR THE CONTROL OF ANAESTHESIA PRODUCED BY THE INFUSION OF ALTHESIN IN PRIMATES
Open Access
- 1 October 1978
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 50 (10) , 993-1001
- https://doi.org/10.1093/bja/50.10.993
Abstract
The continuous infusion of Althesin under electroencephalographic (e.e.g.) control provided a constant level of light anaesthesia for periods of 1–5.5 h during experimental brain hypoxia in spontaneously breathing baboons and Rhesus monkeys. Polygraphic records (respiration, heart rate, arterial pressure, cerebral venous sinus pressure, end-tidal gas concentrations) and also estimation of blood-gas tensions, pH, and concentrations of pyruvate and lactate demonstrated a steady physiological state. Various methods of e.e.g. monitoring were tested to establish an optimal assessment of depth of anaesthesia as a guide to the control of the rate of infusion of Althesin. A purpose-built modification of the Cerebral Function Monitor was found to give unequivocal recognition of changing depths of anaesthesia.This publication has 2 references indexed in Scilit:
- Profound hypoxia in Papio anubis and Macaca mulatta — Physiological and neuropathological effectsJournal of the Neurological Sciences, 1978
- Cyanide intoxication in Macaca mulattaJournal of the Neurological Sciences, 1977