The Genome Sequence of the SARS-Associated Coronavirus
Top Cited Papers
- 30 May 2003
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 300 (5624) , 1399-1404
- https://doi.org/10.1126/science.1085953
Abstract
We sequenced the 29,751-base genome of the severe acute respiratory syndrome (SARS)–associated coronavirus known as the Tor2 isolate. The genome sequence reveals that this coronavirus is only moderately related to other known coronaviruses, including two human coronaviruses, HCoV-OC43 and HCoV-229E. Phylogenetic analysis of the predicted viral proteins indicates that the virus does not closely resemble any of the three previously known groups of coronaviruses. The genome sequence will aid in the diagnosis of SARS virus infection in humans and potential animal hosts (using polymerase chain reaction and immunological tests), in the development of antivirals (including neutralizing antibodies), and in the identification of putative epitopes for vaccine development.Keywords
This publication has 20 references indexed in Scilit:
- Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory SyndromeScience, 2003
- Robert KochMicrobes and Infection, 2003
- The N-Terminal Domain of the Murine Coronavirus Spike Glycoprotein Determines the CEACAM1 Receptor Specificity of the Virus StrainJournal of Virology, 2003
- Generation of a Replication-Competent, Propagation-Deficient Virus Vector Based on the Transmissible Gastroenteritis Coronavirus GenomeJournal of Virology, 2002
- The Pfam Protein Families DatabaseNucleic Acids Research, 2002
- Gapped BLAST and PSI-BLAST: a new generation of protein database search programsNucleic Acids Research, 1997
- Tandem Placement of a Coronavirus Promoter Results in Enhanced mRNA Synthesis from the Downstream-Most Initiation SiteVirology, 1996
- CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceNucleic Acids Research, 1994
- Improved tools for biological sequence comparison.Proceedings of the National Academy of Sciences, 1988
- Sequence analysis of the bovine coronavirus nucleocapsid and matrix protein genesVirology, 1987