In Vitro Synergy of Daptomycin plus Rifampin against Enterococcus faecium Resistant to both Linezolid andVancomycin
Open Access
- 1 December 2005
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 49 (12) , 5166-5168
- https://doi.org/10.1128/aac.49.12.5166-5168.2005
Abstract
In vitro synergy testing of daptomycin plus rifampin was performed against 24 unique isolates of Enterococcus faecium resistant to both linezolid and vancomycin. Synergy testing showed that 21/24 (88%) were synergistic and 3/24 (12%) were indifferent by the Etest method. Time-kill assays revealed synergy for 18/24 (75%) and indifference for 6/24 (25%).Keywords
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