Design and analysis of chromosome physical mapping experiments
- 29 June 1994
- journal article
- research article
- Published by The Royal Society in Philosophical Transactions Of The Royal Society B-Biological Sciences
- Vol. 344 (1310) , 329-335
- https://doi.org/10.1098/rstb.1994.0071
Abstract
Mathematical and statistical aspects of constructing ordered-clone physical maps of chromosomes are reviewed. Three broad problems are addressed: analysis of fingerprint data to identify configurations of overlapping clones, prediction of the rate of progress of a mapping strategy and optimal design of pooling schemes for screening large clone libraries.Keywords
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