Potentiation of Lathyrogenic Effect of Beta Aminopropionitrile in Turkey Poults.

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Abstract
Cyanoacetic acid (CAA) produced no toxicity symptoms when fed to turkey poults in quantities which induced relatively high blood levels. Two known inhibitors of monoamine oxidase, isonicotinic acid hydrazide and l-isonlcotinyl-2-isopropyl hydrazine at 0.04-0.08% of the diets were also not toxic, but when fed at the same levels in combination with BAPN, the characteristic toxicity symptoms of the latter substance were greatly enhanced. This is interpreted as the result of a decreased in vivo conversion of BAPN to CAA. N-propylamine at 0.5-1.0% of the diet did not itself produce toxic symptoms, but it enhanced the toxicity of BAPN.

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