Effects of Clozapine on Psychiatric Symptoms, Cognition, and Functional Outcome in Schizophrenia
- 1 November 1999
- journal article
- conference paper
- Published by American Psychiatric Association Publishing in The Journal of Neuropsychiatry and Clinical Neurosciences
- Vol. 11 (4) , 481-489
- https://doi.org/10.1176/jnp.11.4.481
Abstract
This study focused on the symptomatic and cognitive effects of the atypical antipsychotic clozapine in chronic hospitalized schizophrenia patients. Further, it explored how these effects might be related to discharge, an important functional outcome. Patients were assessed at baseline and at regular intervals with clinical instruments and a cognitive battery. Clozapine treatment produced symptomatic and cognitive improvements, positive changes that appeared to occur independently of one another. Baseline cognitive performance, as well as cognitive change with treatment, predicted discharge. Further investigation of the effects of clozapine and other atypical antipsychotics on cognition and functional outcome is warranted.Keywords
This publication has 1 reference indexed in Scilit:
- The comparative efficacy and long-term effect of clozapine treatment on neuropsychological test performanceBiological Psychiatry, 1994