A COMPARISON OF OESTRIOL AND OESTRADIOL IN THE FEMALE RAT
- 1 January 1958
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 27 (1) , 73-76
- https://doi.org/10.1530/acta.0.0270073
Abstract
Estradiol has 100 to 1000 times the activity of estriol to effect cornification of cervix and vagina, disappearance of leukocytes from the vagina and hypertrophy of the uterine horns of the spayed rat. In spayed animals, estriol is almost as potent as estradiol in causing the development of a stratified epithelium in cervix and vaginal tissue. Estriol causes deposition of PAS (periodic acid Schiff reagent) staining neutral mucopolysaccharides in the epithelia of the vagina and the cervix provided no cornification occurs. These results confirm the studies of Puck and Hubner (Puck, A. and Hubner, K. A., Acta Endocrinol. 22 200, 1956.) in guinea pigs and rabbits and suggest that estriol is not merely a substance with weak estrogenic activity but a hormone with specific activities especially on the uterine cervix and on the vagina. MDS.Keywords
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