Intraadrenal mechanisms of DHEA regulation: A hypothesis for adrenopause
- 12 June 2001
- journal article
- review article
- Published by Georg Thieme Verlag KG in Experimental and Clinical Endocrinology & Diabetes
- Vol. 109 (02) , 75-82
- https://doi.org/10.1055/s-2001-14826
Abstract
Dehydroepiandrosterone (DHEA) and its sulfate metabolite DHEAS are the major androgens secreted by the human adrenal gland. The specific control of these hormones remains unclear. While ACTH is a potent stimulator of DHEA secretion, other factors both systemic and local have been involved in adrenal androgen control. Here we review the extra and intra-adrenal regulation of DHEA and propose a hypothetical model for adrenal senescence.Keywords
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