The Effect of Breathing Oxygen on the Radiosensitivity of the Rabbit Lens and the Use of Oxygen in X-Ray Therapy

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Abstract
In relation to the principle of differential tumor sensitization by O2, put forward by Gray et al, it is of interest to known the effect of breathing oxygen on the radio-sensitivity of normal tissues, particularly those where cells are some distance from capillary blood. In one such tissue, the lens epithelium in the eye of the rabbit, the radiosensitivity is increased by 24 [plus or minus] 6% when O2 at 1 atmosphere pressure is given. This was established from observations on the fall of glutathione in the irradiated lenses. The physiology of the transport of O2 to the lens is considered. Quantitative data from this and other work are discussed in relation to the use of O in radiotherapy.

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